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本文对265例慢性HBV无症状感染者进行了临床—病理—病毒学研究,结果表明:肝内HBV DNA存在游离型、游离—整合型和整合型三种分子状态,或肝内HBV感染发展的三个时相。表达于血液的HBV感染过程为:处于传染时相的病毒携带,非传染时相的抗原携带,以及病毒清除后仅残留于肝内的基因组携带。游离型HBV DNA是病毒的复制状态,表达为HBeAg、HBcAg和血清HBV DNA;血清HBsAg水平与之呈平行关系,但难以划分传染与非传染时相的界限值;抗HBe亦不是否定血液传染时相的标志。表明病毒感染状态的大多数参数,在不同肝组织病变间无明显差别,可能由于慢性无症状感染者的低免疫应答性以及病变可能主要是对长期感染的组织反应积累的结果。
In this paper, 265 patients with chronic HBV infection asymptomatic clinical - pathology - virology study showed that: intrahepatic HBV DNA exist free, free - integration and integration of three molecular states, or the development of intrahepatic HBV infection Three phases. The process of HBV infection expressed in the blood is carried by the virus in the phase of infection, the antigen carried in the non-infectious phase, and the genome left in the liver only after the virus is cleared. Free HBV DNA is a replication state of the virus, expressed as HBeAg, HBcAg and serum HBV DNA; serum HBsAg levels parallel with it, but difficult to divide the boundaries of infection and non-infectious phase; anti-HBe is not negative blood transmission Sign of the phase. Most of the parameters indicating the status of the virus infection were not significantly different between the different liver tissue lesions, possibly due to the low immune responsiveness of the chronic asymptomatic infection and the lesion may be mainly the result of the accumulation of tissue responses to long-term infection.