论文部分内容阅读
目的:分析总结近年来药源性肝损害的情况。方法:应用《中国生物医学文献数据库》从1990～2001年进行逐年检索,将符合药源性肝损害诊断标准的文献进行收集分析。结果:抗结核病药、中药制剂和免疫抑制剂是引起肝损害最常见的药物,联合应用具有肝毒性的药物可使药源性肝损害的发生率增高,肾移植者联合应用免疫抑制剂可引起急性肝衰竭,已成为药源性肝损害死亡的主要原因。结论:应重视抗结核病药、免疫抑制剂和某些中药制剂引起的肝损害,肾移植者在应用免疫抑制剂治疗时应特别注意监测肝功能。
Objective: To analyze and summarize the drug-induced liver damage in recent years. Methods: The “Chinese Biomedical Literature Database” was searched from 1990 to 2001 year by year. The documents that meet the diagnostic criteria of drug-induced liver damage were collected and analyzed. Results: Anti-tuberculosis drugs, traditional Chinese medicine preparations and immunosuppressive agents are the most common drugs that cause liver damage. Combined use of drugs with hepatotoxicity can increase the incidence of drug-induced liver damage. Combined use of immunosuppressive agents in renal transplant recipients may cause Acute liver failure, has become the leading cause of drug-induced liver damage. Conclusion: It is important to pay attention to anti-tuberculosis drugs, immunosuppressive agents and liver damage caused by certain traditional Chinese medicine preparations. Special attention should be paid to monitoring liver function in renal transplant recipients when immunosuppressive agents are used.