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近年来利用~(125)碘-脱氧尿嘧啶核苷(~(125)IUdR)掺入测定造血系统功能已有不少报道,例如测定造血干细胞周期的不同参数,造血干细胞及祖细胞的增殖能力以及γ线照射小鼠造血系统残余损伤等。实践证明这种测试手段可以作为研究造血功能的一种工具。 Huber等给受致死剂量照射的受体小鼠输注适量小鼠骨髓细胞,在照后3—6天,每天测定增殖活力(脾中~(125)IUdR掺入量)。在一定限度内,输入骨髓细胞数与~(125)IUdR呈线性相关。作者认为本法可以用于测试造血
In recent years, the use of ~ (125) Iodo-deoxyuridine (~ (125) IUdR) incorporation assay hematopoietic system has been reported, for example, different parameters of the hematopoietic stem cell cycle, hematopoietic stem cell and progenitor cell proliferation And γ ray irradiation mouse hematopoietic system residual damage and so on. Practice has proved that this test can be used as a tool to study hematopoietic function. Huber et al. To recipient mice exposed to a lethal dose, appropriate amounts of mouse bone marrow cells were infused and proliferative activity (~ (125) IUdR incorporation in the spleen) was measured daily at 3-6 days after irradiation. Within a certain limit, the number of input bone marrow cells with ~ (125) IUdR linear correlation. The authors believe this law can be used to test hematopoiesis