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目的探讨血清C-反应蛋白(CRP)及降钙素原(PCT)检测对于儿童血液细菌感染的临床诊断价值。方法收集2013年1月-2015年1月收治的血液细菌感染患儿42例作为观察组,同期非血液细菌性感染患儿53例作为对照组,检测和比较2组的CRP及PCT水平,比较2组的阳性率。结果观察组的PCT水平显著高于对照组(P<0.05),且其阳性率为92.86%,显著高于对照组的15.09%(P<0.05);观察组的平均CRP水平显著高于对照组(P<0.05),但阳性率仅为30.95%,与对照组的28.30%无显著性差异(P>0.05);PCT的诊断灵敏度、特异度、阳性及阴性预测值、诊断符合率分别为92.86%、84.91%、82.98%、93.75%、88.42%,显著高于CRP的50.00%、67.92%、55.26%、63.16%、60.00%(P<0.05),PCT联合CRP后提高至97.62%、90.57%、89.13%、97.96%、93.68%。结论PCT对于儿童血液细菌感染的诊断敏感性优于CRP,可作为儿童血液细菌感染监测和诊断的特异性指标,将PCT与CRP联合应用可提高诊断效能。
Objective To investigate the clinical diagnostic value of serum C-reactive protein (CRP) and procalcitonin (PCT) in children with bacterial infection of blood. Methods 42 children with bacterial infection of blood from January 2013 to January 2015 were selected as observation group and 53 children with non-blood bacterial infection during the same period as control group. CRP and PCT levels in two groups were detected and compared The positive rate of 2 groups. Results The PCT level in the observation group was significantly higher than that in the control group (P <0.05), and the positive rate was 92.86%, significantly higher than that in the control group (15.09%, P <0.05). The mean CRP level in the observation group was significantly higher than that in the control group (P <0.05), but the positive rate was only 30.95%, which was not significantly different from the control group (28.30%) (P> 0.05). The diagnostic sensitivity, specificity, positive and negative predictive value of PCT were 92.86 (P <0.05). Compared with CRP, PCT increased significantly to 97.62% and 90.57% after PCT combined with CRP, , 89.13%, 97.96%, 93.68%. Conclusions PCT is more sensitive to the diagnosis of bacterial infection of blood in children than CRP, which can be used as a specific indicator of blood bacterial infection monitoring and diagnosis in children. Combined application of PCT and CRP can improve the diagnostic efficacy.