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目的 探讨儿童过敏性紫癜 (AP)合并神经系统损害的临床特点、发生机制和预后。方法 对临床诊断明确的 15 2例儿童AP患者进行回顾性研究 ,结合文献予以讨论。结果 伴有神经症状者 2 7例 (17 8% ) ,主要为头痛头晕、精神障碍、视物模糊、癫疒间 发作和肢体麻木无力等。治疗后 2 7例中 2 1例 (77 8% )痊愈 ,好转 5例(18 5 % ) ,死亡 1例 (3 7% ) ;13例 (48 1% )复发。结论 伴发神经系统损害的AP患者多见于较大龄儿童 ,这种损害既有脑内小血管病变的因素、也有非血管因素 ,神经系统和肾脏一并损害者预后不良
Objective To investigate the clinical features, mechanism and prognosis of Henoch-Schonlein purpura (AP) complicated by nervous system in children. Methods A retrospective study of 152 children with clinically diagnosed AP was conducted and discussed in the literature. Results 27 cases with neurological symptoms (17 8%), mainly headache, dizziness, mental disorders, blurred vision, epileptic seizures and limb numbness and so on. After treatment, 21 cases (77.8%) recovered, 5 cases (18 5%) improved and 1 died (37%); 13 cases (48.1%) relapsed. Conclusions AP patients with neurological damage are more common in older children. Such damage is associated with both small-vessel disease in the brain and non-vascular factors, with poor prognosis in both the nervous system and the kidneys