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儿童哮喘青春期缓解已停发3年以上者16例,静脉取血检测外周血IgE、嗜酸性细胞、嗜碱性细胞值以及分别以粉尘螨浸液(5×10~4g/ml)、扰人IgE(0.1μg/ml),高渗甘露醇作为刺激剂的人嗜碱性细胞释放能力,并以无过敏史、家族史的正常人30例和本院哮喘患者25例进行比较,可观察到青春期缓解组:(1)嗜酸性细胞值增高者为3/16(18.75%)明显低于哮喘组的15/25(60%)(P<0.05),与正常组的1/30(3.33%)无明显差异;(2)IgE值增高者为2/16(12.5%),与正常组的1/30(3.33%)无明显差异,虽低于哮喘组的9/25(36%),但仍无显著性差异;(3)嗜碱性细胞值为9/16(56.25%)与哮喘组的15/25(60%)相仿;明显高于正常组的1/30(3.33%)(p<0.001);(4)以粉尘螨和抗人IgE为刺激剂的HBDT其阳性数均为1/16(6.25%)与正常组的1/30(3.33%)和0/30(0%)相接近,均明显低于哮喘组的15/25(60%)和14/25(56%)(P<0.001),而以甘露醇为刺激剂的HBDT阳性数在青春期缓解组为9/16(56.25%)与哮喘组的19/25(76%)无差异,明显高于正常组的4/30(13.33%)(P<0.001)。表明哮喘在青春期缓解者嗜酸性细胞明显降低,IgE有一定程度下降,而嗜碱性细胞在量和质方面仍存在着异常。
Childhood asthma adolescence has stopped more than 3 years in 16 cases, venous blood to detect peripheral blood IgE, eosinophils, basophils and the value of dust mites immersion (5 × 10 ~ 4g / ml), disturbing IgE (0.1μg / ml), hypertonic mannitol as a stimulator of human basophil release capacity, and non-allergic history, family history of normal subjects in 30 cases and patients with asthma in our hospital compared to 25 cases were observed Puberty remission group: (1) The increase of eosinophils was 3/16 (18.75%) significantly lower than 15/25 (60%) in asthma group (P <0.05) (2) There was no significant difference between the two groups (2/16%, 12.5%) and 1/30 (3.33%) in the normal group, which was lower than that in the asthma group (9/25, 36% (3) basophils with 9/16 (56.25%) were similar to 15/25 (60%) in asthma group and significantly higher than 1/30 (3.33%) in normal group p <0.001). (4) The positive numbers of HBDT with dust mite and anti-human IgE as stimulants were 1/16 (6.25%) and 1/30 (3.33% ) Were significantly lower than those in asthma group 1 5/25 (60%) and 14/25 (56%) (P <0.001), while the positive number of HBDT with mannitol as stimulant was 9/16 (56.25%) in adolescent remission group and 19 / 25 (76%), which was significantly higher than that of the normal group (4/30 (13.33%), P <0.001). That asthma in ejaculation remission eosinophils decreased significantly, IgE decreased to a certain extent, while basophils in quantity and quality are still abnormal.