氧哌嗪青霉素(Piperacillin)是第三代半合成青霉素,具有广谱抗菌作用。近年来在临床应用较多,笔者遇见1例用该药后致脑皮质萎缩死亡,报告如下。 患者男性,42岁,因感冒诱发支气管哮喘于1993年3月31日下午从单位骑自行车去医院门诊。皮试阴性后,给予氧哌嗪青霉素(湖南岳阳制药二厂生产,批号921227,1g/瓶)4g加入4:1液250ml中静脉滴注1分钟时,患者突感胸闷,气急,全身紫绀,自咬断门牙3颗。即肌注肾上腺素1mg、洛贝林3mg,静推地塞米松10mg,吸氧等抢救。测血压8/5.3kPa,呼吸8次/min,心率74次/min,心音低,两肺均闻哮鸣音。静脉注射林可 Piperacillin is the third generation of semi-synthetic penicillin with broad-spectrum antibacterial activity. In recent years, more clinical applications, I met one case of cortical atrophy caused by death of the drug, the report is as follows. Male patient, 42 years old, had bronchial asthma due to a cold and went to the hospital outpatient department by bicycle on the afternoon of March 31, 1993. Skin test negative, given piperacillin penicillin (Hunan Yueyang Pharmaceutical Factory production, lot number 921227, 1g / bottle) 4g added 4: 1 solution 250ml intravenous infusion of 1 minute, the patient suddenly felt chest tightness, shortness of breath, systemic cyanosis, Since the bite off the incisor 3. That intramuscular epinephrine 1mg, Lobelin 3mg, intravenous dexamethasone 10mg, oxygen and other rescue. Blood pressure 8 / 5.3kPa, breath 8 times / min, heart rate 74 beats / min, low heart sound, both lungs smell wheeze. Lin injection