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目的探讨检测血清胱抑素C和尿β2微球蛋白对早期糖尿病肾病的临床诊断价值。方法采用免疫比浊法对60例早期糖尿病肾病患者进行血清胱抑素C和尿β2微球蛋白的结果检测,并与40例健康对照组做比较分析。结果早期糖尿病肾病患者的血清胱抑素C和尿β2微球蛋白的检测结果均较对照组显著增高,差异有统计学意义(P<0.01);糖尿病组血清胱抑素C、β2微球蛋白及联合检测血清胱抑素C、β2微球蛋白的阳性率分别为41.67%、36.67%、65%,均高于正常对照组(P<0.01)。结论血清胱抑素C和尿β2微球蛋白是反映2型糖尿病患者早期肾脏损伤的灵敏且可靠的指标;联合检测对早期发现糖尿病肾病具有重要的临床意义。
Objective To investigate the clinical value of serum cystatin C and urinary β2 microglobulin in the diagnosis of early diabetic nephropathy. Methods Immunocytometry was used to detect the serum cystatin C and urinary β2 microglobulin in 60 patients with early diabetic nephropathy and compared with 40 healthy controls. Results Serum levels of cystatin C and urinary β2 microglobulin in patients with early diabetic nephropathy were significantly higher than those in the control group (P <0.01). Serum levels of cystatin C, β2 microglobulin And the combined detection of serum cystatin C and β2 microglobulin were 41.67%, 36.67% and 65%, respectively, which were higher than those of the normal control group (P <0.01). Conclusions Serum cystatin C and urinary β2-microglobulin are sensitive and reliable indicators of early renal injury in type 2 diabetic patients. Combined detection of them has an important clinical significance in the early detection of diabetic nephropathy.