子宫内膜癌起源于子宫内膜,其发生发展与性激素相关联。无论是内源性或外源性雌激素的持续作用,都能致子宫内膜异常增生,并易发展为腺癌。形态学的变化也证实,不被孕激素对抗的雌激素对子宫内膜的长期刺激,可诱发腺癌的先驱病变,如子宫内膜增生过长、腺瘤样增生、不典型增生以及原位癌等。而孕激素却能阻止子宫内膜上皮和间质内细胞的丝状核分裂,使子宫内膜呈分泌期改变,分泌亢进。故有理由设想利用孕激素来影响子宫内膜 Endometrial cancer originated in the endometrium, the occurrence and development associated with sex hormones. Whether endogenous or exogenous estrogen continued role, can cause abnormal endometrial hyperplasia, and easy to develop into adenocarcinoma. Morphological changes also confirmed that long-term stimulation of estrogen, which is not progesterone confrontation, can induce adenocarcinoma of the pioneer lesions, such as endometrial hyperplasia, adenomatous hyperplasia, dysplasia and in situ Cancer and so on. And progesterone can prevent the endometrial epithelium and interstitial cells of the mitotic division, the endometrium was secretory phase change, hypersecretion. So there are reasons to imagine the use of progesterone to affect the endometrium