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目的探讨术前鉴别卵巢良、恶性肿瘤及早期诊断卵巢癌的新方法。方法应用流式细胞仪检测了146例卵巢肿瘤患者外周血T淋巴细胞亚群以及血清CA125的表达水平。结果外周血T淋巴细胞亚群、血清CA125检测卵巢癌的灵敏度、特异度分别为74.6%、68.1%;81.0%、74.7%。联合外周血T淋巴细胞亚群及血清CA125检测卵巢癌的灵敏度、特异度分别为93.7%、91.6%。结论利用外周血T淋巴细胞亚群与CA125联合检测,将明显提高卵巢癌诊断的灵敏度和特异度,有较大的临床应用价值。
Objective To explore the new method of differentiating benign and malignant ovarian tumors and diagnosing ovarian cancer early. Methods Flow cytometry was used to detect the expression of T lymphocyte subsets and serum CA125 in 146 patients with ovarian tumors. Results The sensitivity and specificity of detecting serum T-lymphocyte subsets and serum CA125 in ovarian cancer were 74.6%, 68.1%, 81.0% and 74.7% respectively. The sensitivity and specificity of combined peripheral blood T lymphocyte subsets and serum CA125 in detecting ovarian cancer were 93.7% and 91.6%, respectively. Conclusion The combined detection of T lymphocyte subsets and CA125 in peripheral blood will significantly improve the sensitivity and specificity of the diagnosis of ovarian cancer, which has great clinical value.