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目的:制备黄芩苷-PEG 4000固体分散体并研究黄芩苷的分散状态及其熔解过程的热力学性质。方法:采用熔融法制备黄芩苷-PEG4000固体分散体,用差示扫描量热法确定黄芩苷-PEG 4000物理混合物及固体分散体中黄芩苷熔解过程的热力学参数。结果:与物理混合物相比,固体分散体中黄芩苷的熔解焓较小,熔解过程的相变协同性较大。随着PEG 4000比例增大,固体分散体中黄芩苷的熔解温度、熔解焓和熔解相变协同性都逐渐增大。结论:黄芩苷在固体分散体中以微晶的形态存在,增大PEG 4000的比例将使黄芩苷在微观形态上更加均一。
OBJECTIVE: To prepare baicalin-PEG 4000 solid dispersion and study the dispersion state and the thermodynamic properties of baicalin. Methods: Baicalin-PEG4000 solid dispersion was prepared by melt method. The thermodynamic parameters of baicalin melting process in baicalin-PEG 4000 physical mixture and solid dispersion were determined by differential scanning calorimetry. Results: Compared with the physical mixture, the enthalpies of baicalin in the solid dispersion were smaller and the phase transition synergism in the melting process was larger. With the PEG 4000 increasing, the melting temperature, enthalpy of melting and phase transition synergism of baicalin in solid dispersions all increased gradually. CONCLUSIONS: Baicalin exists as a crystallite in a solid dispersion. Increasing the PEG 4000 ratio will result in a more uniform baicalin profile at the microscopic morphology.