目的　探讨实验兔的使用次数对热原敏感性产生的影响。方法　用不同使用次数的实验兔进行试验 ,对同一实验兔注射统一规定剂量的细菌内毒素 ,然后每间隔 30min测量实验兔体温一次 ,共 8次。结果　随着实验兔使用次数的增加 ,其体温升高幅度逐渐降低。结论　实验兔在多次使用后对热原的敏感性降低 Objective To investigate the effect of the use of experimental rabbits on pyrogen sensitivity. Methods The experiment rabbits with different times of use were used to test. The same experimental rabbits were injected with a uniform dose of bacterial endotoxin, and the body temperature of rabbits was measured once every 30 minutes for a total of 8 times. Results With the increasing use of experimental rabbits, the temperature rise gradually decreased. Conclusion Experimental rabbits after repeated use of pyrogen reduced sensitivity