新生儿坏死性小肠结肠炎(necrotizing enteroco-litis,NEC)是新生儿最常见的胃肠道急危重症,90%发生于早产儿,极低出生体重儿的发病率约为7%,NEC患儿占新生儿重症监护病房(NICU)住院患儿的1%～5%,其病死率高达20%～50%[1-2]。近年来虽然对NEC进行了大量的研究,发现早产、人工喂 Neonatal necrotizing enterocolitis (necrotizing enteroco-litis, NEC) is the most common neonatal gastrointestinal critical illness, 90% occurred in premature children, the incidence of very low birth weight children was about 7%, NEC Accounted for 1% to 5% of hospitalized neonatal intensive care unit (NICU), the mortality rate as high as 20% to 50% [1-2]. In recent years, although a large number of NEC conducted a study, found that premature birth, artificial feeding