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目的:观察小儿柴桂退热颗粒辅助治疗儿童上呼吸道感染的临床疗效,及对患儿血清超敏C-反应蛋白(hs-CRP)、中性粒细胞百分比(GR)的影响。方法:选取116例上呼吸道感染患儿,按随机数字表法分为治疗组与对照组,每组58例。2组均给予抗炎、抗病毒等常规对症治疗,治疗组在此基础上加用小儿柴桂退热颗粒。评估临床疗效,观察治疗前后患儿hs-CRP及GR的变化。结果:治疗组总有效率94.83%,对照组总有效率75.86%。2组比较,差异有统计学意义(P<0.05)。治疗组退热时间、止涕时间均短于对照组,差异均有统计学意义(P<0.05)。2组咽部红肿消退时间比较,差异无统计学意义(P>0.05)。治疗后,2组hs-CRP水平及GR均较治疗前下降,差异均有统计学意义(P<0.05);治疗组hs-CRP水平及GR均比对照组下降更明显,差异均有统计学意义(P<0.05)。结论:采用小儿柴桂退热颗粒辅助治疗儿童上呼吸道感染,可显著改善患儿的临床症状、体征,提高治疗效果。
Objective: To observe the clinical curative effect of Chai Gui Jiere Jue Feizi Granule in children with upper respiratory tract infection and its effect on serum hs-CRP and the percentage of neutrophil (GR) in children. Methods: 116 children with upper respiratory tract infection were selected and divided into treatment group and control group according to random number table method, with 58 cases in each group. Both groups were given anti-inflammatory, anti-virus and other conventional symptomatic treatment, the treatment group on the basis of pediatric Chai Gui heat particles. The clinical efficacy was evaluated, and the changes of hs-CRP and GR in children before and after treatment were observed. Results: The total effective rate was 94.83% in the treatment group and 75.86% in the control group. The difference between the two groups was statistically significant (P <0.05). The treatment group fever back time, shorten the lead time are shorter than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the regression time between two groups (P> 0.05). After treatment, the levels of hs-CRP and GR in both groups were significantly lower than those before treatment (all P <0.05). The levels of hs-CRP and GR in the treatment group were significantly lower than those in the control group Significance (P <0.05). Conclusion: The treatment of upper respiratory tract infection in children with Chai Gui Tiugui Granule can significantly improve the clinical symptoms and signs of children and improve the therapeutic effect.