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目的为探讨氨甲苯酸和抑肽酶的止血疗效。方法将３４例成人心脏手术患者分为３组，Ａ组于体外循环（ＣＰＢ）前、中、后给予氨甲苯酸共７５０ｍｇ；Ｂ组ＣＰＢ中给予抑肽酶２００万Ｕ；并设一对照组。结果氨甲苯酸使ＣＰＢ中激活全血凝固时间（ＡＣＴ）明显缩短，追加肝素量较另两组显著增加（Ｐ＜０．０５），２４小时胸液量较对照组减少２３％（Ｐ＞０．０５）。抑肽酶使ＣＰＢ中ＡＣＴ略延长，与对照组相比无统计学意义，对肝素用量无影响，２４小时胸液减少３５％（Ｐ＜０．０５）。两用药组术中术后库血用量均显著减少（Ｐ＜０．０１），术后胸液量相似（Ｐ＞０．０５）。结论氨甲苯酸止血疗效弱并缩短ＡＣＴ及明显增加肝素用量，不如抑肽酶疗效可靠。
Objective To explore the hemostatic effect of aminomethyl benzoate and aprotinin. Methods Thirty-four adult patients undergoing cardiac surgery were divided into 3 groups: group A received 750 mg aminomethyl benzoate before, during and after cardiopulmonary bypass (CPB); 2 mg aprotinin was given to group B in CPB; and a control group . Results Trimellitic acid significantly shortened the activation of whole blood in CPB, and the additional heparin volume increased significantly (P <0.05) compared with the other two groups. The amount of pleural fluid in 24 hours was 23% lower than that in the control group (P> 0 .05). Aprotinin slightly prolonged the ACT in CPB, compared with the control group was not statistically significant, no effect on the amount of heparin, pleural effusion 24 hours reduced by 35% (P <0.05). The volume of postoperative blood banked in both groups was significantly decreased (P <0.01), and the amount of pleural effusion was similar after operation (P> 0.05). Conclusion Aminoclopramide has a weak curative effect of hemostasis and a shortened ACT and obviously increased heparin dosage. It is not as effective as aprotinin.