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消抗安胎液 (XKAT)为新研制的治疗不孕症的纯中药制剂。本文初步探讨了男性血清抗精子抗体(AsAb)和可溶性白细胞介素 2受体 (sIL - 2R)水平的关系 ,发现血清AsAb的产生和sIL - 2R水平变化呈一定关系。对于AsAb阳性的男性不育患者经服用XKAT治疗观察发现 :AsAb转阴率达 84.6% ;并且血清中sIL - 2R水平也下降 (P <0 .0 1)。提示XKAT可能通过抑制T淋巴细胞的活化 ,从而影响机体体液免疫与细胞免疫功能 ,发挥治疗作用。
XKAT is a newly developed pure Chinese medicine preparation for the treatment of infertility. In this article, the relationship between male serum anti-sperm antibody (AsAb) and soluble interleukin 2 receptor (sIL-2R) levels was initially investigated. It was found that serum AsAb production was related to changes in sIL-2R levels. For patients with AsAb positive male infertility treated with XKAT, the negative rate of AsAb was 84.6%; and the level of sIL-2R in serum was also decreased (P < 0.01). It is suggested that XKAT may play a therapeutic role by inhibiting the activation of T lymphocytes, thereby affecting the body’s humoral and cellular immune functions.