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本文报道一组既有原发性胆汁性肝硬化(PBC)又有自身免疫性慢性活动性肝炎(CAH)特征的4例患者。其中3例女性,1例男性,年龄25～64岁,3例无症状,1例有瘙痒和黄疸。均无酗酒、输血和规则服药史,体检仅1例有肝肿大。 实验室检查:4例血清AST、ALT、AP、GGT均升高,白蛋白均正常,3例的IgM正常。胆固醇、胆红素和IgG各有1例升高。4例抗线粒体抗体(AMA)、抗M_2和抗双股DNA抗体均阴性,平滑肌抗体(SMA)和抗核抗体(ANA)均阳性。HBV和HCV标记均阴性。B超检查均无胆道扩张和胆囊疾病,2例ERCP检
This article reports a group of 4 patients with both primary biliary cirrhosis (PBC) and autoimmune chronic active hepatitis (CAH). Three of the women, one male, aged 25-64 years, three asymptomatic, and one had itching and jaundice. No alcoholism, blood transfusion and regular medication history, physical examination only 1 case of hepatomegaly. Laboratory tests: serum AST, ALT, AP, GGT were elevated in 4 cases, albumin were normal, 3 cases of IgM normal. Cholesterol, bilirubin and IgG increased in 1 case. Four cases of anti-mitochondrial antibodies (AMA), anti-M_2 and anti-double-stranded DNA antibodies were negative, smooth muscle antibodies (SMA) and antinuclear antibodies (ANA) were positive. Both HBV and HCV markers were negative. B ultrasound examination without biliary dilatation and gallbladder disease, 2 cases of ERCP test