目的探讨化脓性眼内炎治疗失败原因。方法化脓性眼内炎63例，6例采用传统的常规治疗，23例单纯玻璃体腔内注药，34例采用玻璃体腔注药及玻璃体切除术。结果显效13例占20．6％，有效15例占23．8％，无效35例占55．6％。结论未能早期诊断并在48小时内玻璃体腔注射抗生素及未切除玻璃体是眼内炎治疗失败的重要原因。药物敏感试验尚无结论者可选用头孢唑啉钠2．25mg玻璃体腔注射。 Objective To investigate the causes of suppurative endophthalmitis failure. Methods Septic endophthalmitis in 63 cases, 6 cases of conventional conventional treatment, 23 cases of simple intravitreal injection, 34 cases of vitreous cavity injection and vitrectomy. The results showed that 13 cases accounted for 20.6%, effective 15 cases accounted for 23.8%, ineffective 35 cases accounted for 55.6%. Conclusion The failure of early diagnosis and the intravitreal injection of antibiotics and unresectable vitreous within 48 hours are the main reasons for the failure of endophthalmitis treatment. Drug sensitivity test is not conclusive choice cefazolin sodium 2.25mg intravitreal injection.