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为观察穿心莲有效成分（ＡＰＩ０１３４）对凝血酶作用下血小板活化的抑制作用，将家兔２４只随机分为ＡＰＩ０１３４（Ａ）组（ｎ＝９），噻氯匹定（Ｔ）组（ｎ＝８）和对照组（ｎ＝７），治疗１周，然后检测凝血酶作用下血小板内ｃＡＭＰ、ｃＧＭＰ和胞浆游离钙离子浓度，以及血小板超微结构。结果表明ｃＡＭＰ水平在Ａ、Ｔ两组显著高于Ｃ组（Ｐ＜０．０５），而胞浆游离钙离子浓度明显低于Ｃ组（Ｐ＜０．０１），超微结构表明Ａ组和Ｔ组血小板脱颗粒现象较Ｃ组明显减轻。在Ａ和Ｔ组之间各项参数均无统计学差异。结论：ＡＰＩ可抑制凝血酶诱导的血小板活化反应
To observe the inhibitory effect of API0134 on platelet activation induced by thrombin, 24 rabbits were randomly divided into three groups: ) And control group (n = 7) for 1 week. The concentrations of cAMP, cGMP and cytoplasmic free calcium in platelets and the ultrastructure of platelets were measured by thrombin. The results showed that the level of cAMP in A and T groups was significantly higher than that in C group (P <0.05), while the level of cytoplasmic free calcium was significantly lower than that in C group (P <0.01) T group platelet degranulation significantly reduced compared with the C group. There was no significant difference in the parameters between A and T groups. Conclusion: API can inhibit thrombin-induced platelet activation