论文部分内容阅读
氧化应激在帕金森病(PD)发病过程中发挥着重要作用。过氧化物酶体增殖物激活受体γ辅激活因子1α(PGC-1α)是新出现的在抗氧化应激系统中起关键作用的转录调节因子,氧化应激激活的PGC-1α能够诱导抗氧化酶表达,提高组织抗氧化能力。沉默信息调节因子2相关酶类1(SIRT1)是最近发现的烟酰胺腺嘌呤二核苷酸依赖的蛋白去乙酰化酶类,SIRT1去乙酰化PGC-1α后阻止了蛋白酶体降解PGC-1α,而产生靶基因持续激活。SIRT1/PGC-1α在氧化应激时能够调节许多抗氧化程序表达,在预防和治疗PD中发挥重要作用。现就SIRT1/PGC-1α抗氧化应激在PD保护中的作用予以综述。
Oxidative stress plays an important role in the pathogenesis of Parkinson’s disease (PD). Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a newly emerged transcriptional regulator that plays a key role in the antioxidant stress system. Oxidative stress-activated PGC-1α is able to induce resistance Oxidase expression, improve tissue antioxidant capacity. SIRT1, a recently discovered nicotinamide adenine dinucleotide dependent protein deacetylase class, blocks proteasomal degradation of PGC-1α following SIRT1 deacetylation of PGC-1α, The resulting target genes are continuously activated. SIRT1 / PGC-1α regulates the expression of many anti-oxidants during oxidative stress and plays an important role in the prevention and treatment of PD. The role of SIRT1 / PGC-1α in the protection of PD against oxidative stress is reviewed.