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目的:分析磷酸西格列汀在2型糖尿病患者中的降糖效果,探究其对胰岛功能保护作用。方法:随机选取2015年6月——2016年5月45例2型糖尿病患者作为观察组,采用磷酸西格列汀+盐酸二甲双胍治疗。选取同期45例2型糖尿病患者作为对照组,单纯给予盐酸二甲双胍治疗,对比2组患者临床治疗效果。结果:2组治疗后HbA1c、血糖均有所下降,胰岛素、C肽上升,但是观察组改善程度更为明显,与对照组治疗后相比,存在明显差异(P<0.05)。结论:在常规给药基础上,联合应用磷酸西格列汀,可明显改善患者血糖水平,并对胰岛功能产生较强保护作用。
OBJECTIVE: To analyze the hypoglycemic effect of sitagliptin phosphate in patients with type 2 diabetes mellitus (T2DM) and explore its protective effect on islet function. Methods: Forty-five patients with type 2 diabetes mellitus were selected randomly from June 2015 to May 2016. Patients were treated with sitagliptin phosphate and metformin hydrochloride. Forty-five patients with type 2 diabetes mellitus at the same period were selected as the control group, treated with metformin hydrochloride alone, and the clinical effects were compared between the two groups. Results: The levels of HbA1c, blood glucose and the level of insulin and C-peptide increased in both groups after treatment. However, the improvement in the observation group was more obvious. Compared with the control group, there was a significant difference (P <0.05). Conclusion: On the basis of conventional administration, the combination of sitagliptin phosphate can significantly improve the blood glucose level of patients and has a strong protective effect on pancreatic islet function.