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目的通过测定新生儿血清25-羟维生素D[25(OH)D]、甲状旁腺激素(PTH)、钙、磷浓度,了解兰州市新生儿维生素D营养状况,指导临床补充维生素D。方法选取2012年9~12月在兰州大学第一医院住院的90例新生儿为研究对象,早产儿30例,足月儿60例,采用酶联免疫法检测两组患儿生后10天内血清25(OH)D、PTH浓度,并分析两者之间的相关性;血清标本的钙、磷水平由贝克曼AU 2700全自动生化分析仪测定。结果早产儿血清25(OH)D浓度为(21.9±2.5)nmol/L,显著低于足月儿(34.9±10.8)nmol/L,差异有统计学意义(P<0.05);早产儿血清PTH浓度为(94.7±40.2)pg/ml,显著高于足月儿(56.1±30.0)pg/ml,差异有统计学意义(P<0.05),新生儿血清25(OH)D水平与PTH呈负相关;早产儿血钙浓度为(2.1±0.3)mmol/L,低于足月儿(2.3±0.3)mmol/L,差异有统计学意义(P<0.05);早产儿血磷浓度为(1.8±0.7)mmol/L,足月儿为(1.6±0.5)mmol/L,差异无统计学意义(P>0.05)。结论兰州市新生儿普遍存在维生素D缺乏或不足的现象,应加强孕母和新生儿的维生素D补充。
Objective To investigate the nutritional status of neonatal vitamin D in neonates and to guide clinical vitamin D supplementation by measuring serum 25-hydroxyvitamin D [25 (OH) D, PTH, calcium and phosphorus in neonates. Methods Ninety newborns hospitalized in the First Hospital of Lanzhou University from September to December in 2012 were enrolled in this study. 30 premature infants and 60 full-term infants were enrolled in this study. Enzyme linked immunosorbent assay 25 (OH) D, PTH concentrations were analyzed and the correlation between them was analyzed. The calcium and phosphorus levels of serum samples were determined by Beckman AU 2700 automatic biochemical analyzer. Results Serum 25 (OH) D concentrations in preterm infants were (21.9 ± 2.5) nmol / L, significantly lower than those in term infants (34.9 ± 10.8) nmol / L, with significant difference (P <0.05) (94.7 ± 40.2) pg / ml, significantly higher than that of term infants (56.1 ± 30.0) pg / ml, the difference was statistically significant (P <0.05). The serum 25 (OH) (2.1 ± 0.3) mmol / L in preterm infants, which was lower than that in term infants (2.3 ± 0.3) mmol / L, with significant difference (P <0.05) ± 0.7 mmol / L, and full-term children were (1.6 ± 0.5) mmol / L, with no significant difference (P> 0.05). Conclusion Newborns in Lanzhou generally have a deficiency or deficiency of vitamin D, and should be supplemented with vitamin D for pregnant women and newborns.