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目的观察贝前列素联合波生坦对中重度肺动脉高压(PH)的疗效。方法 30例中重度PH患者采用常规治疗及波生坦治疗,观察组在此基础上加用贝前列素钠,观察用药前后患者肺动脉收缩压(SPAP)、肺动脉平均压(mPAP)及肺动脉舒张压(DPAP)并进行统计学比较。结果贝前列素与波生坦联用可较单独应用波生坦更有效地改善肺动脉压,两药联合治疗组SPAP和mPAP均显著降低,且两种治疗方案的不良反应发生率低。结论贝前列素与波生坦联合治疗可能是PH安全有效的治疗方案。
Objective To observe the curative effect of beraprost and bosentan on moderate and severe pulmonary hypertension (PH). Methods Thirty patients with moderate to severe PH were treated with conventional therapy and bosentan. The observation group was given beraprost sodium to observe the changes of pulmonary arterial systolic pressure (SPAP), pulmonary arterial pressure (mPAP) and pulmonary artery diastolic pressure (DPAP) and statistical comparison. Results The combination of beraprost and bosentan could improve pulmonary arterial pressure more effectively than bosentan alone. The combination of both drugs significantly reduced both SPAP and mPAP, and the incidence of adverse reactions was lower in the two treatment regimens. Conclusion The combination of beraprost and bosentan may be a safe and effective PH treatment.