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目的探讨血管内皮生长因子(VEGF)与2型糖尿病患者视网膜病变(DR)之间的关系。方法将52例2型糖尿病患者分为31例糖尿病视网膜病变组(DR组)和21例糖尿病视网膜无病变组(NDR组),又将DR组分为背景型糖尿病患者视网膜病变组(BDR组)19例和增值型糖尿病患者视网膜病变组(PDR组)12例。分别检测各组VEGF值并与36例正常对照组进行比较。结果正常对照组、糖尿病组、NDR组、BDR组及PDR组VEGF含量(pg/ml)分别为108.4±27.2、185.2±32.6、162.3±28.7、220.3±44.6和201.9±31.7。糖尿病组和正常对照组相比,差异有高度统计学意义(均P<0.01);BDR、PDR与NDR组相比,差异均有统计学意义(均P<0.05),PDR与BDR相比,差异亦有统计学意义(P<0.05)。结论 VEGF可作为了解糖尿病视网膜病变程度的参考指标。
Objective To investigate the relationship between vascular endothelial growth factor (VEGF) and type 2 diabetic retinopathy (DR). Methods 52 patients with type 2 diabetes were divided into 31 diabetic retinopathy group (DR group) and 21 diabetic retinopathy group (NDR group), and DR group was divided into diabetic retinopathy group (BDR group) 19 cases and diabetic retinopathy group (PDR group) 12 cases. The VEGF value of each group was detected and compared with 36 normal control group. Results The VEGF levels (pg / ml) in normal control group, diabetic group, NDR group, BDR group and PDR group were 108.4 ± 27.2, 185.2 ± 32.6, 162.3 ± 28.7, 220.3 ± 44.6 and 201.9 ± 31.7, respectively. Compared with the normal control group, there was a significant difference between the diabetic group and the normal control group (all P <0.01). There was significant difference between the BDR, PDR and NDR groups (all P <0.05) The difference was also statistically significant (P <0.05). Conclusion VEGF can be used as a reference to understand the degree of diabetic retinopathy.