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目的探讨以尿总蛋白肌酐比(TPCR)分组评价糖尿病早期肾损伤的应用价值。方法分析61例正常组和113例2型糖尿病(2型DM)组,测量其尿液5项指标;以尿TPCR分≥200mg/gCr组与<200mg/gCr组2组,分析113例与另外67例2型DM患者组,测量其尿TPCR、α-L-岩藻糖苷酶(AFU)、亮氨酸氨基肽酶(LAP)、β2-微球蛋白(β2-MG)、尿微量清蛋白(mAlb)、尿转铁蛋白(TF)和血肌酐(Cr)、血清胱抑素-C(CysC)各5～6种指标。结果正常对照组与2型DM患者组、113例2型DM患者TPCR≥200mg/gCr组与TPCR<200mg/gCr组,其尿TPCR、mAlb、β2-MG、LAP、AFU5种指标均跟随TPCR而显著增高,统计学差异显著(P<0.001)。67例2型DM患者TPCR≥200mg/gCr组尿TPCR、mAlb、TF以及血清CysC均高于TPCR<200mg/gCr组,统计学差异明显(P<0.05)。结论以TPCR200mg/gCr分组或为界线是判别糖尿病人早期肾损害程度的可靠指标。
Objective To investigate the value of urinary total protein creatinine ratio (TPCR) in the evaluation of diabetic early renal injury. Methods 61 cases of normal group and 113 cases of type 2 diabetes mellitus (type 2 DM) were enrolled in this study. Urine five indexes were measured. Urine TPCR score of 200mg / gCr group and <200mg / gCr group were divided into two groups. Sixty-seven patients with type 2 diabetes mellitus (T2DM) were enrolled in this study. Their urinary TPCR, α-L-fucosidase (AFU), leucine aminopeptidase (LAP), β2-microglobulin (mAlb), urinary transferrin (TF) and serum creatinine (Cr), serum cystatin C (CysC) of 5 to 6 kinds of indicators. Results TPCR≥200mg / gCr group and TPCR <200mg / gCr group in 113 patients with type 2 diabetes mellitus were significantly higher than those in type 2 diabetes mellitus group. The urinary TPCR, mAlb, β2-MG, LAP, Significantly increased, statistically significant difference (P <0.001). 67 cases of type 2 DM patients with TPCR≥200mg / gCr urinary TPCR, mAlb, TF and serum CysC were higher than the TPCR <200mg / gCr group, statistically significant difference (P <0.05). Conclusion TPCR200mg / gCr group or borderline is to determine the degree of early diabetic renal damage a reliable indicator.