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目的观察培美曲塞(PEM)和卡铂(CBP)联合腹腔内温热灌注顺铂治疗铂类敏感的复发上皮性卵巢癌的疗效和不良反应。方法病理确诊为复发性晚期上皮性卵巢癌患者32例,采用PEM 500mg/m2+CBP 200mg/m2+腹腔灌注顺铂60mg治疗,每21天重复1次。评价近期疗效及不良反应。结果 32例中,部分缓解15例,病情稳定16例,病情进展1例。中位疾病进展期8.7个月,中位生存期17.8个月。主要不良反应为血液学毒性、胃肠道反应、疲劳和过敏反应等。结论 PEM和CBP联合腹腔内温热灌注顺铂治疗复发晚期上皮性卵巢癌,疗效确切,耐受性较好。
Objective To observe the efficacy and side effects of pemetrexed (PEM) and carboplatin (CBP) in combination with intraperitoneal warm cisplatin in the treatment of platinum-sensitive recurrent epithelial ovarian cancer. Methods Thirty-two patients with recurrent advanced epithelial ovarian cancer were enrolled in the study. The patients were treated with PEM 500mg / m2 + CBP 200mg / m2 + intraperitoneally with cisplatin 60mg every 21 days. Evaluation of the recent efficacy and adverse reactions. Results 32 cases, partial remission in 15 cases, stable condition in 16 cases, 1 case of disease progression. The median progression of 8.7 months, the median survival of 17.8 months. The main adverse reactions were hematological toxicity, gastrointestinal reactions, fatigue and allergic reactions. Conclusion PEM and CBP combined intraperitoneal warm cisplatin in the treatment of recurrent advanced epithelial ovarian cancer, the curative effect is exact and well tolerated.