0引言肿瘤耐药是肿瘤治疗失败最为重要的原因之一,癌症患者如果失去了手术根除病灶的时机便很少再有通过化疗治愈的可能。肿瘤细胞可通过多种机制引发耐药:减少细胞内药物的浓度,如P-糖蛋白(P-gp)介导的肿瘤多药耐药;加快药物的分解代谢;细胞内药物靶点的表达发生改变或突变;癌 0 Introduction Tumor drug resistance is one of the most important reasons for the failure of cancer treatment. Cancer patients rarely have the chance of being cured by chemotherapy if they have lost the opportunity to eradicate the disease. Tumor cells can initiate resistance through a variety of mechanisms: reducing intracellular drug concentrations, such as P-gp-mediated multidrug resistance; accelerating drug catabolism; and expressing intracellular drug targets Change or mutation; cancer