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目的研究孕11-13周胎儿鼻骨(NB)长度的95%参考值范围及其意义。方法回顾性选择2010年1月1日至2010年9月30日在我院产检门诊就诊的单胎孕妇661例(剔除最后确诊为唐氏综合征的病例),均为孕11-13w,通过超声NB测量,计算正常11-13周胎儿鼻骨均数,标准差及95%参考值范围,第2.5百分位数。结果正常11-13周胎儿鼻骨长度均数2.847 mm,标准差为0.794 mm,其95%的参考值范围为2.053~3.641mm,第2.5百分位数是1.598 mm。结论胎儿NB长度是进行唐氏综合征筛查的指标之一,通过计算孕早期胎儿NB长度的95%的参考值范围,为临床上唐氏综合征筛查提供数据参考并应用于孕早期血清学筛查工作,以提高唐氏筛查的准确率。
Objective To investigate the 95% reference range of fetal nasal bone (NB) length during 11-13 weeks gestation and its significance. Methods A retrospective review was conducted on 661 singleton pregnant women (excluding those who were finally diagnosed as Down’s syndrome) from January 1, 2010 to September 30, 2010 in our antenatal clinics. All were pregnant 11-13w, Ultrasound NB measurement, calculate the normal 11-13 weeks fetal nasal bone mean, standard deviation and 95% of the reference range, the second percentile. Results The average length of nasal bone of fetuses with a normal range of 11-13 weeks was 2.847 mm with a standard deviation of 0.794 mm. The 95% reference range was 2.053 ~ 3.641 mm and the second percentile was 1.598 mm. Conclusion Fetal NB length is one of the indexes for Down’s syndrome screening. By calculating the 95% reference range of fetal NB length in first trimester, it provides a reference for clinical Down’s syndrome screening and is applied to early pregnancy serum Learn to screen to improve the accuracy of Down’s screening.