托吡酯系一种新型抗癫痫药。文中采用随机双盲法对比了托吡酯与安慰剂治疗难治性部分性癫痫的疗效与安全性。181例难治性部分性癫痫患者为本研究对象。平均年龄37岁。大多数为男性白族人。90％以上伴有复杂部分性癫病病史，近2／3有继发广泛性癫痫病史。大多数病人合用两种抗癫 Topiramate is a new antiepileptic drug. The efficacy and safety of topiramate combined with placebo in the treatment of refractory partial epilepsy were compared in a randomized, double-blind manner. 181 patients with refractory partial epilepsy as the object of this study. The average age is 37 years old. Mostly male Bai people. More than 90% of patients with complicated partial epilepsy history, nearly 2/3 have a history of secondary generalized epilepsy. Most patients combined two antiepilepsy