自Korting等(1965)报告了应用Gestagen治疗泛发性硬皮病有效之后,Rau等(1972)及本文作者等也曾应用此药治疗泛发性硬皮病,获得显著疗效。但其作用机转未明。本文就Gestagen用药前后,检查尿中粘多糖量及其电泳分带情况,根据所得结果,探讨治疗机理。对象及方法:6例泛发性硬皮病住院患者均为女性,年龄24～49岁,浮肿期2例,硬化期4例。用药方法:初次每日10毫克(1例为20毫克)连服20天,休药一周后再服药15毫克/日于治疗前后的一定期间内连续留24小时尿3天以便检查。(1)尿粘多醣量:用三甲基鲸蜡溴化铵使粘多醣沉淀,再用卡巴 Since Korting et al. (1965) reported the effectiveness of Gestagen in the treatment of generalized scleroderma, Rau et al. (1972) and the authors of this article have also used this medicine in the treatment of patients with generalized scleroderma and achieved significant results. But its role is not clear. In this paper, before and after Gestagen medication, check the amount of mucopolysaccharide in urine and electrophoresis bands, according to the results obtained, to explore the mechanism of treatment. PARTICIPANTS AND METHODS: Six patients with generalized scleroderma were female, aged from 24 to 49 years, with two cases of edema and four cases of sclerosis. Medication Methods: The first daily 10 mg (1 case of 20 mg) even for 20 days, a week after taking medicine and taking 15 mg / day before and after treatment for a certain period of continuous stay 24 hours urine for 3 days to check. (1) the amount of urine mucopolysaccharide: Mucopolysaccharide precipitation with trimethyl-cetyl ammonium bromide, then Kabat