论文部分内容阅读
目的探讨女性冠心病患者的冠状动脉病变特点。方法将经冠状动脉造影确诊的女性冠心病患者 87例 ,根据年龄将其分为 4组 ,即女性绝经前 ( <45岁 )、围绝经期 ( 4 5～ 5 4岁 )、绝经后 ( 5 5～ 6 4岁 )和老年期 (≥ 6 5岁 ) ;将同期确诊的男性患者 2 0 6例亦按此方法分组进行对照。结果女性冠心病患者在绝经前和围绝经期多支病变者显著少于同年龄男性组 (分别为 0与 5 3.0 6 % ,9.0 9%与6 0 .34% ,P均 <0 .0 1) ,冠状动脉病变积分显著低于男性组 (分别为 7.5± 3.5与 12 .5± 5 .5 ,8.5± 6 .5与 14 .0± 5 .5 ,P<0 .0 1～0 .0 0 1) ,但自绝经后期开始 ,冠状动脉多支病变者显著增加 ,与同年龄男性组无差异 ( P>0 .0 5 ) ;冠状动脉病变积分亦无差异 (分别为14 .5± 5 .7与 16 .0± 4.5 ,19.5± 4.5与 19.0± 7.5 ,P均 >0 .0 5 )。与围绝经期以前患者比较 ,冠状动脉多支病变者显著增多 (分别为 5 .7%与 5 9.6 1% ,P<0 .0 1) ,冠状动脉病变积分亦显著增加 (平均 17.0± 5 .1与 8.0± 3.5 ,P<0 .0 1)。各支冠状动脉狭窄程度无差异 ,以左前降支受累率最高。结论与年龄有关的雌激素变化对女性冠心病患者的冠状动脉病变进程有明显影响
Objective To investigate the characteristics of coronary lesions in women with coronary heart disease. Methods Eighty-seven women with coronary heart disease diagnosed by coronary angiography were divided into 4 groups according to their ages: premenopausal women (<45 years old), menopausal women (45-54 years old), menopausal women (<5 years old) 5 ~ 6 4 years old) and the elderly (≥ 65 years old); the same period, 206 cases of male patients were also grouped by this method for comparison. Results In women with coronary heart disease, premenstrual and perimenopausal women with multivessel disease were significantly less than those of the same age group (0 vs 53.6%, 9.09% and 60.34%, respectively, P <0.01 ), Coronary artery disease score was significantly lower than the male group (7.5 ± 3.5 and 12.5 ± 5.5, 8.5 ± 6.5 and 14.0 ± 5.5, P <0.01 ~ 0 .0 However, since the late menopause, there was a significant increase in multiple coronary lesions with no difference between men and women of the same age (P> 0.05). There was no difference in coronary artery disease scores (14.5 ± 5 .7 vs 16.0 ± 4.5, 19.5 ± 4.5 vs 19.0 ± 7.5, P> 0.05). Compared with patients before perimenopause, coronary multivessel disease patients were significantly increased (57.7% vs. 59.61%, P <0.01), and coronary artery disease scores were significantly increased (17.0 ± 5% on average). 1 and 8.0 ± 3.5, P <0.01). The degree of coronary stenosis was no difference, the highest rate of involvement of the left anterior descending artery. Conclusion Age-related estrogen changes have a significant effect on the progression of coronary lesions in women with coronary heart disease