以抗溴氰菊酯品系家蝇 (Del- R)为试材 ,测定了 NIA对溴氰菊酯的增效作用 ,结果表明 :NIA对溴氰菊酯有极显著的增效作用。此后对 NIA的增效机理进行了研究 ,实验证明 :NIA可抑制家蝇体内羧酸酯酶的活性 ,I50 值分别为 2 .14(± 0 .2 2 )× 10 -7mol· L-1(α- NA)和 1.0 9(± 0 .39)× 10 -9mol· L-1(β- NA) ,NIA为 4 .2 0× 10 -4 mol· L-1时 ,其对多功能氧化酶的抑制率达 78.6 3(± 0 .13) % ;此外 ,NIA对神经靶标部位的 ACh E也有抑制作用 ,I50 值为2 .37(± 0 .6 9)× 10 -5mol· L-1。几方面综合作用的结果 ,使其表现出明显的增效效果。 The effect of NIA on deltamethrin was determined using Del-R resistant to deltamethrin. The results showed that NIA had a remarkable synergistic effect on deltamethrin. After that, the mechanism of synergism of NIA was studied. Experiments show that NIA can inhibit the activity of carboxylesterase in housefly, the I50 values ​​are respectively 2.14 (± 0.22) × 10 -7 mol · L -1 ( α-NA) and 1.09 (± 0.39) × 10 -9 mol·L-1 (β-NA) and NIA was 4.2 × 10 -4 mol · L -1 The inhibitory rate reached 78.6 3 (± 0.13)%. In addition, NIA also inhibited the ACh E at the nerve target site, and the I50 value was 2.37 (± 0.96) × 10 -5 mol · L -1. Several aspects of the combined effect of the results so that it showed significant synergies.