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目的探讨乳腺化生性癌(MC)的临床病理学特点。方法回顾性分析6例乳腺化生性癌的临床及病理学特点,其中包括2例鳞状细胞癌,3例含有鳞状细胞癌成分的腺癌(伴有鳞状分化的腺癌),1例癌伴间叶分化。对所有肿瘤组织进行形态学及免疫组化观察,结合临床资料进行分析并复习相关文献。结果 6例化生性癌患者均为女性,发病年龄30~70岁,平均53.5岁。临床上多以无痛性乳房肿块为首发症状,均行手术治疗。免疫组化显示伴有鳞状分化的腺癌中除1例ER和PR(+)外,其余ER、PR均(-);上皮标记物CK7、CK8、CK5、34βE12和E-cad均(+),p63部分(+);癌伴间叶分化中,间叶成分S-100、vimentin、SMA和CD10(+),ER和PR(+)均在导管癌区域表达;1例伴有鳞状分化的腺癌和1例鳞状细胞癌EGFR(+);6例cerb B-2均(-)。结论 MC是罕见的乳腺恶性肿瘤,病理形态学表现为多样性,免疫组化显示多数激素受体(-),根据化生的成分不同表达相应的上皮及间叶组织抗原。
Objective To investigate the clinicopathological features of mastocarcinoma (MC). Methods The clinical and pathological features of 6 cases of mastocarcinoma were retrospectively analyzed. Among them, 2 cases were squamous cell carcinoma, 3 cases were adenocarcinoma with squamous cell carcinomas (with squamous differentiation adenocarcinoma) and 1 case Cancer with mesenchymal differentiation. Morphological and immunohistochemical observation of all tumor tissues, combined with clinical data analysis and review of relevant literature. Results 6 cases of metaplastic cancer patients were female, the age of onset of 30 to 70 years, mean 53.5 years. More clinically painless breast lumps as the first symptom, are underwent surgical treatment. Immunohistochemistry showed that ER, PR were all (-) except for one case of ER and PR (+) in squamous cell adenocarcinoma; epithelial markers CK7, CK8, CK5, 34βE12 and E- ), and p63 (+). S-100, vimentin, SMA and CD10 (+), ER and PR (+) were all expressed in ductal carcinoma in mecca. Differentiated adenocarcinoma and 1 case of squamous cell carcinoma EGFR (+); 6 cases of cerb B-2 were (-). Conclusion MC is a rare malignant tumor of the breast. The pathological features are diverse. Immunohistochemistry shows that most of the hormone receptors (-) express the corresponding epithelial and mesenchymal antigens according to the components of the metaplasia.