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目的：探讨重型颅脑损伤患者术中应用硬脑膜预减张缝合治疗预防术中恶性脑膜出的效果。方法选择我院重型颅脑损伤行大骨瓣减压术患者90例，其中观察组45例行标准大骨瓣减压时预减张缝合硬脑膜，对照组45例行标准大骨瓣减压，硬脑膜直接敞开，比较分析两组临床效果。结果观察组术中无恶性脑膨出，术中出血量少，术后并发症发生率低，明显降低了死亡率。结论对合并有弥漫性脑肿胀及迟发性颅内血肿可能导致术中急性脑膨出的患者采取预减张缝合硬脑膜可取得较好疗效，可降低死亡率，提高生存率。“,”Objective To investigate the effect of using relaxation suture in advance apply to prevent malignant cephalocele in the patient with severe craniocerebral injury during operation. Methods Choosed 90 patients with severe craniocerebral injury after sufficient skull decompression in our hospital. 45 patients’ endocranium in observation group were applied to relaxation suture in advance in sufficient skull decompression. 45 patients’ endocranium in control group were unrestricted in sufficient skull decompression .Compared and analysised the clinical result between the two groups. Results The observation group had no patient with malignant cephalocele after the endocranium was dealing with relaxation suture. The quantity of bleeding during operation were much less than the control group. The occurrence rate of postoperative complication was lower than the control group. Conclusions Relaxation suture apply to endocranium in the patients combining with diffuse swell in brain tissue and tardive intracranial hematoma which may lead to acute cephalocele during operation have preferable curative effect,can reduce the death rate and enhance the rate of survival.