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目的观察罗格列酮治疗糖尿病合并原发性高血压的临床疗效。方法将58例糖尿病伴高血压患者分为观察组30例和对照组28例,观察组给予罗格列酮4 mg/d,对照组服用二甲双胍片,1500 mg/d;观察两组患者治疗前后血压、空腹血糖、餐后2 h血糖、糖化血红蛋白和肝肾功变化,疗程两个月。结果治疗前后两组患者肝肾功无明显变化,治疗后两组血压、空腹血糖、餐后2 h血糖、糖化血红蛋白水平与治疗前比较有显著性差异(P<0.05);观察组与对照组治疗后各项指标比较有显著性差异(P<0.05)。结论罗格列酮治疗糖尿病伴原发性高血压疗效明确。
Objective To observe the clinical efficacy of rosiglitazone in the treatment of diabetes complicated with essential hypertension. Methods Fifty-eight patients with diabetes mellitus were divided into observation group (30 cases) and control group (28 cases). Rosiglitazone 4 mg / d in the observation group and metformin tablet 1500 mg / d in the control group. Before and after treatment Blood pressure, fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin and liver and kidney function, treatment for two months. Results Before and after treatment, there was no significant change in liver and kidney function between the two groups. After treatment, the blood pressure, fasting blood glucose, postprandial 2-hour blood glucose and glycosylated hemoglobin were significantly different from those before treatment (P <0.05) After treatment, the indicators were significantly different (P <0.05). Conclusion Rosiglitazone treatment of diabetes with essential hypertension clear effect.