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枣尺蠖核型多角体病毒 (CzNPV)天津毒株对小白鼠急性毒性试验结果表明 ,小白鼠一次性灌胃处理 ,2周内未引起异常表现 ,体重增长、日饮水、日取食等与对照组无显著差异 ;动物病理学肉眼检查均正常 ,涂血片检查 ,白细胞分类正常 ;组织切片 ,试验组与对照组肝细胞均出现轻度变性 ,肾小球近曲小管上皮细胞多数颗粒变性 ,个别细胞坏死 ,其他器官细胞切片均未见异常。表明CzNPV对小白鼠急性毒性试验安全。
The acute toxicity test of juvenile Zizyphus jujuba nucleopolyhedrovirus (CzNPV) strain in Tianjin showed that the mice were treated with one-time gavage without any abnormal performance, body weight gain, daily drinking water, daily feeding, etc. compared with the control There was no significant difference between the two groups; animal pathology was normal by naked eye examination, smear examination and normal white blood cell classification; slight degeneration of hepatocytes in the tissue sections, test group and control group, most of glomerular proximal tubule epithelial cells degeneration, Individual cell necrosis, other organ cell sections were not abnormal. CzNPV showed acute toxicity test in mice.