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目的探讨血液透析滤过(HDF)对长期血液透析(HD)患者难治性高血压的疗效。方法将23例长期血液透析患者难治性高血压随机分为两组,A组应用标准HD治疗;B组在标准HD基础上,每月增加2次HDF,两组透析都在联合应用降压药物基础上进行,均为每次4h,每周2次,治疗3个月,比较两组患者治疗前后平均动脉压、尿素氮、肌酐的变化。结果B组患者平均动脉压较A组明显下降,而血尿素氮和肌酐下降的程度两组无明显差别。结论血液透析滤过对长期透析患者难治性高血压的治疗效果优于血液透析,且操作简单易学,易于基层医院开展。
Objective To investigate the effect of hemodiafiltration (HDF) on refractory hypertension in long-term hemodialysis (HD) patients. Methods Twenty-three long-term hemodialysis patients with refractory hypertension were randomly divided into two groups. Group A was treated with standard HD. Group B received HDF twice a month on the basis of standard HD. On the basis of drugs, both for 4h, 2 times a week for 3 months, the changes of mean arterial pressure, urea nitrogen and creatinine before and after treatment were compared between the two groups. Results The mean arterial pressure in group B was significantly lower than that in group A, but there was no significant difference between the two groups in the level of blood urea nitrogen and creatinine. Conclusion Hemodiafiltration is superior to hemodialysis in the treatment of refractory hypertension in long-term dialysis patients. It is easy to learn and easy to operate in primary hospitals.