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从1978年9月～1979年8月,利用我们自己建立的免疫扩散自显影技术,在北京地区,对953例13～40妊周妊妇血中甲胎蛋白的含量作了测定。根据无妊娠合并症,末次月经日期准确经随访查阅病历,得知分娩单胎健康婴儿的695名妊妇血中甲胎蛋白含量,首次绘制出我国妊妇血中甲胎蛋白正常值分布。与英国、美国和日本的报告结果是一致的。并以此确定了筛选异常胎儿的临界值,为今后大规模普查或临床常规诊断神经管缺损提供了依据。经过这次测试证明,免疫扩散放射自显影技术是一个适合临床常规使用的简便方法。
From September 1978 to August 1979, using our own self-developed immunodiffusion technique, the levels of alpha-fetoprotein in 953 pregnant women of 13 to 40 gestational weeks in Beijing were determined. According to no pregnancy complications, the last menstrual date accurate follow-up access to medical records, that the birth of singleton fetus healthy 695 pregnant women in the blood of alpha-fetoprotein content, for the first time to draw the blood of pregnant women in China alpha-fetoprotein normal distribution. The results of the report with the United Kingdom, the United States and Japan are consistent. And to determine the screening of abnormal fetal critical value for the future large-scale general screening or clinical diagnosis of neural tube defects provide a basis. After this test proved that immune diffusion autoradiography technology is a simple and convenient method for clinical routine use.