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本实验用免疫组化的方法检测了人低分化鼻咽癌单克隆株（ＣＮＥ－２Ｚ－Ｈ５）体内传代过程中裸鼠移植瘤和回复培养的肿瘤细胞中ＣＤ４４粘附分子的表达及其与转移的关系。结果表明；不同代之间裸鼠移植瘤和回复培养的肿瘤细胞中ＣＤ４４粘附分子的表达有差异。其中第四代裸鼠移植瘤和回复培养的肿瘤细胞ＣＤ４４粘附分子的表达明显高于原代移植瘤及原代细胞（Ｐ＜０．０５）。裸鼠移植瘤中ＣＤ４４粘附分子的表达与肿瘤转移率成正相关关系。结果提示：ＣＤ４４粘附分子的表达与鼻咽癌转移关系密切。
In this study, immunohistochemistry was used to detect the expression of CD44 adhesion molecules in xenografts of nude mice and tumor cells in response to in vivo passage of human poorly differentiated nasopharyngeal carcinoma monoclonal (CNE-2Z-H5) Transfer of the relationship. The results showed that there were differences in the expression of CD44 adhesion molecules between different generations of transplanted tumor in nude mice and in the tumor cells repaired. The expression of CD44 adhesion molecules in the fourth generation of xenografts and tumor cells was significantly higher than that of primary xenografts and primary cells (P <0.05). The expression of CD44 adhesion molecule in the transplanted tumor of nude mice has a positive correlation with tumor metastasis rate. The results suggest that: CD44 adhesion molecule expression and nasopharyngeal carcinoma metastasis are closely related.