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本发明涉及一种3-异噁唑基乙酸苄酯的化学合成方法。本发明以氯乙酰氯和乙炔为原料,经过经加成、缩环、取代、水解和酯化五步反应提高了收率,为该化合物的合成提供了一种高效合成的方法。本发明方法的主要步骤如下:将乙炔、氯乙酰氯、催化剂三氯化铝和四氢呋喃溶剂加入到反应釜中,反应结束后,分离得1,4-二氯-3-丁烯酮;将1,4-二氯-3-丁烯酮和硫酸羟铵加入甲醇或乙醇溶剂中,控制反应温度,反应得到3-氯甲基异噁唑;制备3-异噁唑乙腈;将3-异噁唑乙腈加入盐酸中,水
The present invention relates to a chemical synthesis of benzyl 3-isoxazolyl acetate. In the invention, chloroacetyl chloride and acetylene are used as raw materials, and the yield is increased through five steps of addition, condensation, substitution, hydrolysis and esterification, thereby providing an efficient synthesis method for the synthesis of the compound. The main steps of the method of the present invention are as follows: Acetylene, chloroacetyl chloride, aluminum chloride catalyst and tetrahydrofuran solvent was added to the reaction vessel, the reaction was completed, the isolated 1,4-dichloro-3-butenone; 1 , 4-dichloro-3-butenone and hydroxylammonium sulfate are added into methanol or ethanol solvent to control the reaction temperature to obtain 3-chloromethylisoxazole; 3-isoxazole acetonitrile is prepared; 3- Acetonitrile into hydrochloric acid, water