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偏头痛发生在大约19%的妇女,60%以上的病例头痛发作与月经周期有关。妊娠时头痛完全或部分缓解,而口服避孕药时,当撤退药物的一周中能诱发偏头痛,另外还发现:月经性偏头痛的病人和对照组之间的血浆卵巢激素的浓度无明显不同。因此认为月经前期激素撤退是一个致病因素,Somer-ville 认为主要是雌二醇下降所致。他曾经预防性试用口服或注射雌激素,但由于未能维持足够的血浆雌二醇浓度,放偏头痛的发作无减少。作者利用雌二醇皮下埋藏说明,足以抑制排卵和卵巢周期生化改变的剂量,能够维持血中稳定的雌二醇浓度达6个月,将可预防月经性偏头痛。本文介绍在5年内用雌二醇皮下埋藏治疗24例月经性偏头痛病例的结果。这些病人用其它方法均
Migraine occurs in about 19% of women and in more than 60% of cases cases are related to the menstrual cycle. Headache during pregnancy was completely or partially relieved, whereas oral contraceptives induced migraine during the week when medication was withdrawn. In addition, there was no significant difference in plasma concentrations of ovarian hormones between patients with menstrual migraines and controls. Therefore, the withdrawal of premenstrual hormone is considered a causal factor, Somer-ville that is mainly due to the decline of estradiol. He had tried prophylactically orally or with estrogen, but with no reduction in the number of migraine attacks due to failure to maintain adequate plasma estradiol levels. Using subcutaneous injec- tion of estradiol, the authors report that a stable dose of estradiol in the blood of 6 months, which is sufficient to inhibit ovulation and the biochemical changes in the ovarian cycle, will prevent menstrual migraines. This article describes the results of 24 cases of menstrual migraine treated with subcutaneous burial of estradiol within 5 years. These patients use other methods