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目的:探讨孕酮检测联合β-人绒毛膜促性腺激素(β-HCG)在异位妊娠早期诊断中的应用价值。方法:选取河南省中医院2008年3月～2010年3月临床诊断为异位妊娠的68例患者作为研究组;选取同期就诊的66例正常早孕患者作为对照1组及66例稽留流产患者作为对照2组。三组患者临床资料差异无统计学意义,分别对其进行血β-HCG和孕酮检测并分析。结果:血β-HCG与孕酮检测值对照1组比对照2组和研究组高(P<0.05),对照2组与研究组差异无统计学意义(P>0.05)。以研究组孕酮≤9.33 ng/m l作为临界值,对异位妊娠的灵敏度、特异度、阳性与阴性预测价值进行诊断,分别为87.52%、78.91%、81.24%和71.33%。以研究组血清孕酮水平的第90百分位数9.33 ng/m l联合血β-HCG 2 916.12 mU/m l作为临界值,对异位妊娠的灵敏度、特异度、阳性与阴性预测价值进行诊断,分别为93.76%、63.05%、89.93%和67.08%。结论:对于异位妊娠的诊断,血清孕酮具有一定应用价值,联合血β-HCG和孕酮检测可使异位妊娠诊断的敏感性和特异性得到提高。
Objective: To investigate the value of progesterone detection combined with β-human chorionic gonadotropin (β-HCG) in the early diagnosis of ectopic pregnancy. Methods: Sixty-eight cases of ectopic pregnancy clinically diagnosed as Henan Hospital of Traditional Chinese Medicine from March 2008 to March 2010 were selected as the study group. Sixty-six patients with normal early pregnancy were selected as control group 1 and 66 cases of missed abortion Control 2 groups. The clinical data of three groups showed no significant difference, respectively, the blood β-HCG and progesterone detection and analysis. Results: There was no significant difference between the control group 2 and the study group (P> 0.05). The sensitivity, specificity, positive and negative predictive value of progesterone in the study group ≤9.33 ng / m l as the critical value were 87.52%, 78.91%, 81.24% and 71.33% respectively. The sensitivity, specificity, positive and negative predictive value of ectopic pregnancy were estimated by using the 90th percentile of serum progesterone level 9.33 ng / ml combined with blood β-HCG 2 916.12 mU / ml as the critical value in the study group, Respectively 93.76%, 63.05%, 89.93% and 67.08%. Conclusion: Serum progesterone has certain value in the diagnosis of ectopic pregnancy. The combination of serum β-HCG and progesterone can increase the sensitivity and specificity of diagnosis of ectopic pregnancy.