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目的:研究骨髓增生异常综合征患者病态造血、外周血象与恶性克隆负荷的相关性。方法:回顾分析46例MDS患者,研究MDS骨髓病态造血、外周血象与恶性克隆负荷的相关性。结果:可见双核粒细胞、奇数核红细胞、粒细胞分叶不良与MDS高恶性克隆负荷显著相关(P<0.05);骨髓三系病态造血具有显著较高的克隆负荷(P<0.05);外周血出现幼稚粒细胞是高克隆负荷的指征(P<0.05)。结论:MDS高恶性克隆负荷的指标包括:双核粒细胞、奇数核红细胞、粒细胞分叶不良、三系病态造血、外周血出现幼稚粒细胞。
Objective: To study the relationship between pathological hematopoiesis and peripheral blood count and malignant clonal load in patients with myelodysplastic syndromes. Methods: A retrospective analysis of 46 cases of MDS patients with MDS bone marrow morbidity, peripheral blood and malignant clonal load correlation. Results: The results showed that the number of binucleated granulocytes, odd nucleated erythrocytes and myeloid lobes were significantly correlated with the high malignant clonal load of MDS (P <0.05) The presence of immature granulocytes is indicative of high clonal load (P <0.05). Conclusion: The indexes of high malignant clonal load of MDS include: binuclear granulocytes, odd nucleated erythrocytes, poorly grafted granulocytes, morbid hematopoietic cells of three lines and immature granulocytes in peripheral blood.