论文部分内容阅读
对单用大剂量糖适平（>120mg／d）治疗Ⅱ型糖尿病患者75例的结果作了分析。试验时间5～7个月，每2周测一次空腹及餐后2小时血糖。血糖达到控制的标准订为：空腹≤7．8mmol／L及餐后2小时≤11．lmmol／L。结果：分4种情况，①42例开始时用常规剂量（15～120mg／d），因血糖控制不满意，逐渐加大剂量。血糖逐渐下降达到控制标准，其中最终所用糖适平剂量为＞135mg／d（n=3）、＞150mg／d（n=5）、＞180mg／d（n=22）及210～275mg／d（n=12）；②12例病人因血糖甚高，从开始或两周内，即用180mg/d并持续到试验末。空腹及餐后血糖在2个月内逐渐下降达标；③8例用药情况与①相似，最终剂量平均达190～230mg／d，但试验末只有餐后血糖达标（10．2土0．8mmol／L），空腹血糖未达标；④13例用药情况同①，最终剂量达270mg／d，试验7个月空腹及餐后血糖仍未达标。本组结果说明，在对糖适平一般剂量反应差的糖尿病病人中，有80％以上的病人加大药物剂量可能增加效果，使血糖得到较好的控制，并无更多的低血糖发生。
Analysis of the results of 75 patients with type 2 diabetes mellitus treated with high dose of sugar alone (> 120mg / d). Test time of 5 to 7 months, once every 2 weeks measured fasting and 2 hours postprandial blood glucose. Blood glucose control standards set as: fasting ≤ 7.8mmol / L and 2 hours after meal ≤ 11. lmmol / L. Results: Divided into 4 cases, ① 42 cases started with the conventional dose (15 ~ 120mg / d), due to blood glucose control is not satisfied, and gradually increase the dose. The blood sugar gradually decreased to reach the control standard, and the ultimate dosage of glycyrrhizin was> 135mg / d (n = 3),> 150mg / d (n = 5),> 180mg / d (n = 22) and 210-275mg / d (N = 12); ②12 patients due to high blood sugar, from the beginning or two weeks, that is, with 180mg / d and continued to the end of the test. Fasting and postprandial blood glucose decreased gradually within 2 months; ③ The medication of 8 patients was similar to ①, and the final dose averaged 190-230 mg / d, but only the postprandial blood glucose reached the standard (10.2 ± 0.8 mmol / L ), Fasting blood glucose did not meet the standards; ④ 13 cases of drug use the same ①, the final dose of 270mg / d, 7 months fasting and postprandial blood glucose has not yet reached the standard. This group of results shows that in patients with diabetes mellitus and poor general response to poor response to diabetes patients, more than 80% of patients to increase the dose may increase the effect of blood sugar to get better control, and no more hypoglycemia.