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1984—1990年在马来丝虫病基本消灭地区余杭县,对6个村的人群,用马来丝虫成虫可溶性抗原的ELISA检测血清抗体,进行纵向及横向血清流行病学监测。结果表明在丝虫病基本消灭5年后,人群微丝蚴血症率下降至0,ELISA阳性率和平均消光值均与非丝虫病流行区人群的阳性率(2.53％)和平均消光值(0.17±0.13)相近。纵向监测点检测结果表明10岁以下儿童的ELISA阳性率下降最明显,在丝虫病基本消灭后第3、5年均未检出阳性反应者。同时用ELISA检测班氏丝虫病家及其周围人群的血清抗体,其阳性率为8.33％,且在10岁以下儿童测得阳性反应者。我们认为用马来丝虫成虫抗原的ELISA检测人群血清抗体是一种有效的丝虫病血清学监测方法。低年龄儿童的阳性率可反映该病在当地的传播状况。
From 1984 to 1990, serum antibodies were detected by ELISAs using soluble antigens of malayian filariasis in 6 villages in Yuhang County, where the incidence of male filariasis was basically eliminated, and longitudinal and transverse serological surveillance were conducted. The results showed that after 5 years of the basic elimination of filariasis, the prevalence of microfilariae in the crowd dropped to 0, the positive rate of ELISA and the average extinction value were both positively correlated with the prevalence (2.53%) and the average extinction value (0.17 ± 0.13). Longitudinal monitoring point test results showed that the lowest positive rate of ELISA in children under 10 years of age was the most obvious, in the third and fifth years after the basic elimination of filariasis positive were not detected. At the same time, serum antibodies against Bancroftian filariasis and its surroundings were detected by ELISA. The positive rate was 8.33%, and the positive rate was detected in children under 10 years old. We think using the serum antibodies of the human serum with an ELISA of adult malayian worm antigens is an effective serological surveillance of filariasis. The positive rate of children with low age can reflect the local spread of the disease.