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目的分析不同剂量氟伐他汀治疗老年冠心病心力衰竭的效果、对N-末端脑钠肽前体(NT-pro BNP)及炎性因子水平的影响。方法 80例老年冠心病心力衰竭患者,根据氟伐他汀剂量不同分为甲组及乙组,每组40例。甲组给予40 mg/d氟伐他汀治疗,乙组给予80 mg/d氟伐他汀治疗。观察两组临床疗效。结果甲组有效率(85.00%)与乙组(92.50%)比较差异无统计学意义(P>0.05);治疗后乙组超敏C反应蛋白(hs-CRP)(7.3±3.1)mg/L、NT-pro BNP(571.3±230.2)μg/L低于甲组的(8.4±3.2)mg/L、(816.5±342.3)μg/L(P<0.05);乙组6 min步行距离改善优于甲组,谷丙转氨酶(ALT)、谷草转氨酶(AST)水平高于甲组(P<0.05)。结论在老年冠心病心力衰竭治疗过程中,氟伐他汀疗效确切,有利于降低NT-pro BNP及炎性因子水平,提高生存质量,但大剂量氟伐他汀易导致肝损伤,临床应合理选择药物剂量。
Objective To analyze the effect of different doses of fluvastatin on heart failure in elderly patients with coronary heart disease and the effect of NT-pro BNP and inflammatory cytokines. Methods Eighty elderly patients with coronary heart disease and heart failure were divided into group A and group B according to the dose of fluvastatin, 40 cases in each group. Group A was given fluvastatin 40 mg / d and group B was given fluvastatin 80 mg / d. The clinical effects of two groups were observed. Results The effective rate (85.00%) in group A was not significantly different from that in group B (92.50%) (P> 0.05). The hs-CRP in group B was (7.3 ± 3.1) mg / L (P <0.05). The improvement of walk distance at 6 min in group B was superior to that of group B (571.3 ± 230.2) μg / L and (8.4 ± 3.2) mg / A group, alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels were higher than the A group (P <0.05). Conclusion Fluvastatin is effective in the treatment of heart failure in elderly patients with coronary heart disease, which is beneficial to reduce the levels of NT-pro BNP and inflammatory cytokines and improve the quality of life. However, high-dose fluvastatin can easily lead to liver injury. dose.