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目的:观察消臌软坚丸对肝硬化大鼠肝组织病理学和转化生长因子-α(TGF-α)的影响。方法:采用复合因素造模法复制肝硬化大鼠模型,以复方鳖甲软肝片为对照,观察消臌软坚丸对大鼠肝脏病理形态学和TGF-α的影响。结果:与正常组比较,模型组大鼠肝间质广泛纤维组织增生,将正常肝小叶分割成大小不等的肝细胞团(即假小叶形成),血清和肝组织TGF-α含量明显升高(P<0.05或P<0.01)。与模型组比较,高、低剂量组和对照组肝小叶结构亦受损,少量纤维组织增生,但未见形成间隔。血清和肝组织TGF-α含量明显下降(P<0.05或P<0.01)。结论:消臌软坚丸能显著改善肝硬化大鼠的肝脏病理组织学损害,同时可降低血清和肝组织TGF-α水平,具有显著的抗肝脏纤维化,阻断肝硬化进程的作用,对腹水的产生与消退也产生积极的影响。
Objective: To observe the effect of Xiaopi Ruanjian Pill on hepatic histopathology and transforming growth factor-α (TGF-α) in rats with cirrhosis. METHODS: Rat model of liver cirrhosis was duplicated by compound factor modeling. The compound Biejia Ruangan Tablets was used as a control to observe the effect of Xiaoyu Ruanjian Pills on the pathological morphology and TGF-α of rat liver. RESULTS: Compared with the normal group, the rats in the model group had extensive fibrous tissue proliferation in the hepatic interstitium. The normal hepatic lobules were divided into hepatocytes in different sizes (ie, the formation of false lobules). The levels of TGF-α in the serum and liver tissues were significantly increased. (P<0.05 or P<0.01). Compared with the model group, the structure of the hepatic lobule was also damaged in the high-dose group and the low-dose group and the control group. A small amount of fibrous tissue was found to be hyperplastic but no interval was observed. Serum and hepatic tissue TGF-α content decreased significantly (P<0.05 or P<0.01). Conclusion: Xiaotan Ruanjian Pill can significantly improve liver pathological damage of rats with liver cirrhosis, at the same time, it can reduce serum and hepatic tissue TGF-α levels, has significant anti-hepatic fibrosis, and blocks the process of liver cirrhosis. The occurrence and regression of the government also have a positive effect.