目的　观察玻璃酸酶联合中药外敷用于化疗药物渗漏处皮肤的疗效及具体运用。方法　对 5 3例化疗药物渗漏的病人 ,随机分组。治疗组 2 8例 ,给予玻璃酸酶封闭 ,中药 (活血化瘀止痛膏 )外敷 ;对照组 2 5例 ,给予奴夫卡因、地塞米松封闭 ,如意金黄膏外敷。结果　治疗组显效率 82 14 % ,总有效率 10 0 % ;对照组显效率 5 2 0 0 % ,总有效率 80 %。经 χ2 检验 ,P <0 0 5。两组疗效有显著性差异。结论　玻璃酸酶联合中药外敷用于化疗药物渗漏明显优于传统方法。是目前对化疗药物渗漏的有效治疗方法 Objective To observe the curative effect and specific application of hyaluronidase combined with topical application of traditional Chinese medicine on the skin of patients with chemotherapy drug leakage. Methods Fifty-three patients with chemotherapy-induced drug leakage were randomly divided into two groups. In the treatment group, 28 cases were treated with hyaluronidase and external application of traditional Chinese medicine (activating blood circulation and relieving pain and pain relief cream); while 25 cases in the control group were given Nuvocaine and dexamethasone. Results In the treatment group, the effective rate was 82.14% and the total effective rate was 100%. In the control group, the effective rate was 52.0% and the total effective rate was 80%. After χ2 test, P <0 05. There was significant difference between the two groups. Conclusion The combination of hyaluronidase and traditional Chinese medicine for the chemotherapy drug leakage is obviously better than the traditional method. Is currently an effective treatment of chemotherapy drug leakage