A size-specific aerosol dynamic model is set up to predict the evolution of particle number concentration within a chamber. Particle aggregation is based on the theory of Brownian coagulation, and the model not only comprises particle loss due to coagulation, but also considers the formation of large particles by collision. To validate the model, three different groups of chamber experiments with SMPS (Scanning Mobility Particle Sizer) are conducted. The results indicate that the advantage of the model over the past simple size bin model is its provision of detailed information of size spectrum evolution,and the results can be used to analyze the variations of number concentration and CMD (Count Median Diameter). Furthermore, some aerosol dynamic mechanisms that cannot be measured by instrument can be analyzed by the model simulation, which is significant for better understanding the removal and control mechanisms of ultrafine particles.