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目的 探讨远端胆管癌术后肝转移对预后的影响。方法 对128例远端胆管癌的临床资料进行回顾性分析,采用Kaplan meier法对确定的单因素进行生存率的描述,用卡方检验对各样本率之间进行比较,用logistic回归进行多因素分析,采用 log rank法对单因素进行生存分析评价。结果 肝脏是远端胆管癌术后最常见的转移部位,肝脏转移是远端胆管癌术后主要的死亡原因之一;根治性手术虽然提高了长期生存率,但不能预防肝转移的发生;肿瘤的分化程度和胰腺浸润与肝转移的发生密切相关。结论 远端胆管癌根治性手术后肝转移的积极治疗可望进一步提高远端胆管癌的生存率。
Objective To investigate the effect of postoperative liver metastasis on the prognosis of distal cholangiocarcinoma. Methods The clinical data of 128 patients with distal cholangiocarcinoma were retrospectively analyzed. Kaplan-Meier method was used to describe the single factor survival rate. Chi-square test was used to compare the sample rates. Multiple logistic regression Analysis, the use of log rank method for single factor survival analysis and evaluation. Results The liver was the most common metastatic site of distal cholangiocarcinoma. Liver metastasis was one of the major causes of postoperative death of distal cholangiocarcinoma. Although radical surgery improved long-term survival rate, it did not prevent liver metastasis. The degree of differentiation and pancreatic invasion and liver metastasis are closely related. Conclusion The active treatment of liver metastasis after radical surgery of distal cholangiocarcinoma is expected to further improve the survival rate of distal cholangiocarcinoma.